5 Harmful Biological Effects

5 HARMFUL BIOLOGICAL EFFECTS
5.1	TO HUMANS
Acute Effects
	Describe toxic effects from inhalation, ingestion and skin absorption. Include information on pathological findings if available. State approximate quantities or concentrations which will produce symptoms and serious effects.
Irritation and Sensitization
	Describe any irritant or corrosive effects on the lungs. State whether sensitization by skin contact or inhalation can occur.
Repeated Exposure Effects
	State whether repeated exposure can result in cumulative toxic effects or chronic effects, including carcinogenicity.
Past Experience
	Describe past experience relating to hazards of handling and transporting this material.
5.2	TO OTHER MAMMALS
	Supply all relevant information, including data sources or copies of laboratory reports.
5.2.1	INHALATION TOXICITY
	.1	Acute LC ₅₀:				ppm
		Time, specify: (1 hour or 4 hours are preferred):
		Specify test animal (preferred species is rat):
	.2	Does inhalation of vapours cause allergic sensitization?			YES	NO
		If so, supply details:
	.3	Are the vapours corrosive or strongly irritating?			YES	NO
		If so, supply details:
	.4	Will repeated exposure to vapours cause chronic or cumulative effects?			YES	NO
		If so, supply details:
	.5	Will exposure to the vapour cause a narcotic effect?			YES	NO
		If so, at what concentration?
5.2.2	DERMAL TOXICITY
	.1	Acute LD ₅₀:				mg/kg
		Specify test animal (preferred species is rabbit):
	.2	Is the material readily absorbed by the skin?			YES	NO
	.3	Does the material cause skin sensitization?			YES	NO
		If so, supply details:
	.4	Will repeated exposure to the material cause chronic or cumulative effects?			YES	NO
		If so, supply details:
5.2.3	ORAL TOXICITY
	.1	Acute LD ₅₀:				mg/kg
		Specify test animal (prefered species is rat):
	.2	Will repeated ingestion cause chronic or cumulative effects?			YES	NO
		If so, supply details:
5.2.4	CORROSIVITY TO SKIN (state species used):
	Does the material cause irritation or corrosion to the skin?				YES	NO
	If so, does visible necrosis of the skin occur in: less than
3 minutes?			less than 1 hour?	less than 4 hours?	more than 4 hours?
5.2.5	SPECIFIC TOXIC EFFECTS
	Has the material been tested for specific toxic effects such as neurotoxicity, mutagenicity, teratology or reproductive effects?
	Give details of the results, indicating the species tested:
5.3	TO FISH
	Supply all relevant information, including data sources or copies of laboratory reports.
5.3.1	ACUTE TOXICITY TO AQUATIC ORGANISMS
	Preferably supply 96-hour TLm (the concentration of the substance which will within 96 hours kill 50% of the exposed group of test organisms) with confidence limits.

			(a) a marine fish		(b) a marine crustacean
.1	Subject of test
.2	96-hour TLm
.3	Confidence limits
.4	Method of test (static, static replaced, intermittent flow etc.)
.5	Conditions of test:
	Temperature		°C		°C
	Salinity
	Numbers of animals
	Test volume (litre)
If further information is available, please supply on a separate sheet.
If no information on marine species is available, please supply data on freshwater species.
5.3.2	BIOACCUMULATION IN MARINE ORGANISMS
.1	Rate of uptake:			.3	Tainting potential
	Accumulation factor for uptake:
	Retention time or half-life:
.2	Octanol/water partition coefficient (Log₁₀):			.4	Colouring potential
5.4	OTHER PROPERTIES OF INTEREST IN ENVIRONMENTAL ASSESSMENT CONTEXT
5.4.1	Biodegradability			5.4.5	Lipid solubility:
5.4.2	Chemical oxygen demand:			5.4.6	Biotransformation:
5.4.3	Biochemical oxygen demand:			5.4.7	Reactivity with air:
5.4.4	Reactivity with seawater:			5.4.8	Other (specify):