The expression at the end of this paragraph, "when particular weight is given to additional factors in the hazard profile or to special characteristics of the substance", implies that:
.1 The substance is moderately hazardous or highly hazardous to human health, with an LD50 of less than 50 mg/kg (as expressed by hazard ratings 3 and 4 in column C) and is moderately objectionable with regard to the reduction of amenities (as expressed by a hazard rating XX in column E).